Exploring the role of ventral premotor cortex in reach-to-grasp movements: neural trajectories through spike train similarity space (Talk)
Dimensionality reduction applied to neural ensemble data has led to the concept of a 'neural trajectory', a low-dimensional representation of how the state of the network evolves over time. Here we present a novel neural trajectory extraction algorithm which combines spike train distance metrics (Victor and Purpura, 1996) with dimensionality reduction based on local neighborhood statistics (van der Maaten and Hinton, 2008.) . We apply this technique to describe and quantify the activity of primate ventral premotor cortex neuronal ensembles in the context of a cued reaching and grasping task with instructed delay.